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shaggy

A very cool video about the cutting edge therapeutic potential of phytocannabinoids.

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shaggy

Dr. Dedi Meiri and researchers from Technion, Israel Institute of Technology. Dr. Meiri holds a B.Sc in Biochemistry and a PhD in Plant biotechnology, making him uniquely qualified to investigate the therapeutic potential of phytocannabinoids. Not only are they involved in eight clinical trials but they’re also creating an integrated confidential database to study each strain and its chemical compounds in relation to different ailments. The “Cannabis Database Project” will help future patients and healthcare professionals to effectively recommend strains based on this evidence. His laboratory may be the only one in the world that can identify each and every chemical compound in Cannabis that contributes to the “entourage effect” proposed by Dr. Sanjay Gupta. 

 

 

QUESTION #1: ARE DIFFERENT STRAINS BETTER AT TREATING DIFFERENT TYPES OF CANCERS?

Yes! You can find the answer approximately 26 minutes in.

 

WA5B7dE.png

Cannabinoids treat cancer by causing cell death, a process called Apoptosis. This is a process that all healthy cells have the ability to do in times when they are unneeded or are sick, but cancer cells don’t use this built-in off-switch. Certain cannabinoids force them to do what they should instinctively do, self-destruct. Along the bottom are 12 different extracts made from 12 different Cannabis strains and as you can see, some kill these particular cancer cells better than others.

 


 

QUESTION #2: ARE INDIVIDUAL CANNABINOIDS SUCH AS THC AND CBD EFFECTIVE WHEN USED ALONE?

No! You’ll find the response approximately 27 minutes in.

 

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Just look at all of these organic chemical compounds! There’s almost no doubt in my mind that they have a purpose and it may be necessary to measure more than just those two main cannabinoids.

 


 

QUESTION #3: DO DIFFERENT SOLVENTS AND EXTRACTION METHODS HAVE DIFFERENT EFFECTS ON CANCER?

 

Yes! The response is approximately 28:50 minutes in.

 

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As you can see here, the C02 extraction method performs so much better than the Ethanol extraction method. This expands the number of questions I have! Is it because C02 pulls more cannabinoids than the Ethanol?

 

 

 


Methods of inducing SAR Local Acquired Resistance and Induced Systemic Resistance                                   I.P.M. INTEGRATED PEST MANAGEMENT

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shaggy

CANNABICHROMENE – A CANNABINOID WITH POTENTIAL


What is Cannabichromene? It is one of 119 different identified cannabinoids that are found in the cannabis plant, and is abbreviated as CBC. But that doesn’t mean much to us, so let’s explore its relevance, both in terms of its pharmacology and its chemistry.

 

640px-Cannabichromene-skeletal.svg.png

 


 

PHARMACOLOGY

 

Like most cannabinoids, Cannabichromene can be used in therapeutic settings and beyond. CBC has been shown to have potential as an analgesic or pain reliever. When ingested, it stimulates the descending antinociceptive pathways and several proteins related to nociceptive control. The nociceptive pathway is a 3-neuron chain that recognizes the pain and informs the brain where the pain is located. Abnormalities in nociceptive pathways can lead to pathological pain (chronic pain). This means that CBC could lend itself in the treatment of pathological pain disorders. Given these results the compound seems promising but it must be thoroughly evaluated.

 

 

CBC’s potential role in therapy extends further, as it has been shown to be a possible anti-inflammatory. A study found CBC was just as effective an inflammatory as phenylbutazone (PBZ), but without the toxic side effects. The toxicity of PBZ has resulted in its discontinuation in the US. The authors of the study stated that, given equivalent doses, CBC’s lower toxicity opens up the potential for usage in larger doses. In a separate study, CBC was also shown to reduce gastrointestinal inflammation in specific cases. And, unlike opioids, CBC does not cause constipation.

Furthermore, CBC seems to possess some antimicrobial qualities, described in the literature as “potent” against microbes. The antimicrobial properties were not limited to just common microbes, but also displayed high efficacy against some multidrug resistant strains of S. aureus (MRSA). The mechanism of action is completely different from current antibiotic agents, which may prove useful in treatments down the road. The molecular makeup of the compound could also make it cheap and biodegradable.

Finally the cannabinoid has been shown to be promising as an antidepressant. While THC has shown effectiveness at approximately 2.5mg per kg of body weight, CBC is right behind it at 40-80mg per kg of body weight. The authors of the study stated that, “the non-psychotropic CBC elicited a significant dose-dependant reduction in immobility indicative of antidepressant-like action.” In common parlance, that means that CBC did not have the psychoactive effects of THC, but showed potential as an antidepressant.

 


 

CHEMISTRY/BIOSYNTHESIS

 

Cannabichromene (CBC) is the decarboxylated form of Cannabichromene carboxylic acid (CBCA) and one of three major cannabinoids. It is derived from Cannabigerolic Acid (CBGA), which also serves as the precursor to many cannabinoids, including THC, CBD, and CBC.[1]

 

Canna-Biosynth-Blog-Fig-2.pngCBGA being converted into several different cannabinoids. CBC on the bottom pathway. Image Courtesy of Marijuana.com

The enzyme CBCA synthase catalyzes a reaction between CBGA and Cannabinerolic acid.[2] The ratio that these compounds are found in cannabis is determined by the ratio of enzymes and the activity of their respective genes.

Because cannabis is legally considered a Schedule 1 substance, research into the plant’s genome is highly restricted and has been severely delayed.[3] It wasn’t until very recently that a genomic map had been produced for cannabis. More research is necessary to locate the elusive CBCAS or CBCA synthase gene so that direct modification or artificial selection for CBC can occur.

 


 

CALL TO ACTION

 

If you are interested in seeing how CBC affects yourself, strains that are typically high in CBC include:

  1. 3 Kings
  2. Jorge’s Diamonds #1
  3. Bediol
  4. Landrace strains from India.

Methods of inducing SAR Local Acquired Resistance and Induced Systemic Resistance                                   I.P.M. INTEGRATED PEST MANAGEMENT

                Do plants need silicon?                   ODA finds bottled microbes with little live organisms                          Welcome to Z-Library!

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shaggy

I recently read that sessile trichomes, which are present on all leaf surfaces throughout the plant have been found to be a source of highly pure CBC(A).

The CBC synthase gene may only be expressed in the juvenile state of some cannabis plants.

GWPharm has a mutant that is high in CBC.

 

When needed sessile trichome glandular trichome heads may be collected from vegetative leaves at a reduced yield.

It has been reported that the cannabinoid content of capitate-stalked glands is about 20 times that of capitate-sessile glands.

 

Sessile and large stalked glandular trichomes can be separated using appropriate size filters.

Water/Ice seperation AKA bubble bag method is acceptable, better methods may exist therfore more investigation is recomended.

 

In theory, the resin heads from glandular stalked trichomes (reported typical diameter 75-199 μm) should be trapped on the 73 μm sieve, whilst the sessile trichomes (typically 50 μm) fall through and are caught on the 25 μm mesh.

Maginfication may be needed to verify this theroy.

 

Plants were kept under permanent light for the first two weeks after emergence. Then, to induce flowering, the 24 h photoperiod was dropped to 19 h and further gradually reduced by 15 minutes per day. When the photoperiod reached the level of 11 h, it was kept constant until the end of the experiment. The onset of flowering was visible in all plants by the day the 11 h photoperiod was reached. 

 

I am still unsure how long the plants need to be grown for optimum CBC levels.

Sources

https://patents.justia.com/patent/20160360721

https://patents.google.com/patent/US20110098348A1/en

Edited by shaggyballs

Methods of inducing SAR Local Acquired Resistance and Induced Systemic Resistance                                   I.P.M. INTEGRATED PEST MANAGEMENT

                Do plants need silicon?                   ODA finds bottled microbes with little live organisms                          Welcome to Z-Library!

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shaggy

Edit:

I am not sure why I quoted my own post.

Anyway

Bump...LOL

Edited by shaggyballs

Methods of inducing SAR Local Acquired Resistance and Induced Systemic Resistance                                   I.P.M. INTEGRATED PEST MANAGEMENT

                Do plants need silicon?                   ODA finds bottled microbes with little live organisms                          Welcome to Z-Library!

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